CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 150 enrolled
Drug / intervention
Canalith repositioning maneuver (Epley maneuver) +4 morebehavioral
Likely dose
Not stated in record
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Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00000359
NCT00000359Phase 2Completed

Treatments for Benign Paroxysmal Positional Vertigo (BPPV)

Baylor College of Medicine·interventional·Posted Nov 3, 1999·Updated Jul 26, 2012

In Brief

A Phase 2 clinical trial evaluating Canalith repositioning maneuver (Epley maneuver), Semont maneuver, and 3 other interventions for Vertigo. Completed, enrolled 150 participants across 1 site.

Detailed Summary

The purpose of this study was to determine the relative short- and long-term efficacy of several physical treatment paradigms commonly employed for the treatment of benign paroxysmal positional vertigo (BPPV), including the canalith repositioning (Epley) maneuver, the liberatory (Semont) maneuver, the Brandt-Daroff exercises and nonspecific vestibular habituation exercises. These procedures involve exercises and head manipulations. Vertigo intensity and frequency, the presence/absence of slow-phase eye movements, the degree of dizziness handicap and acts of daily living (ADL) were assessed. The study also ascertained the effects of co-morbid conditions on the response to treatment. While BPPV is a common and significant public health problem that has been recognized for several decades, this is the first systematic study of the relative treatment efficacy of different physical treatment modalities for this disorder.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsVertigo
CountriesUnited States

Timeline

Phase 2CompletedFinished
199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 3, 1999
Enrollment StartOct 1, 1998
Primary CompletionJun 1, 2003
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 26.7 years ago

Interventions

Canalith repositioning maneuver (Epley maneuver)behavioral

Standard passive motion of the head: Dix-Hallpike maneuver, turn head to opposite side, roll over, sit up.

Semont maneuverbehavioral

Sidelying maneuver, flip over 180 deg, sit up.

Brandt-Daroff exercisesbehavioral

Active exercise. Sidelying to involved side, sidelying to uninvolved side, sit up.

Vestibular habituation exercisesbehavioral

Head shaking exercises in pitch, roll, yaw and circumduction. Titrating from 2 repetitions per exercise to 20 repetitions per exercise, as tolerated.

ShamManeuverbehavioral

Passive movement of the head