At a glance
ClinicalIndex Comparison RecordPhase 3Completed
Drug / intervention
antihypertensive agents +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease (MRFIT)
In Brief
A Phase 3 clinical trial evaluating antihypertensive agents, smoking cessation, and 2 other interventions for Cardiovascular Diseases and 3 related conditions. Completed.
Detailed Summary
To determine for a group of men at high risk of death from coronary heart disease whether a special intervention program to lower serum cholesterol, reduce blood pressure, and eliminate cigarette smoking would result in a significant reduction in mortality from coronary heart disease.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
Countries--
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI)
Timeline
Phase 3CompletedFinished
1971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
Enrollment StartJun 1972
Study CompletionJul 1998
First PostedOct 1999
TodayJul 2026
First PostedOct 28, 1999
Enrollment StartJun 1, 1972
Study CompletionJul 1, 1998
TodayJul 2, 2026
Posted 26.7 years ago
Interventions
antihypertensive agentsdrug
smoking cessationbehavioral
diet, fat-restrictedbehavioral
diureticsdrug