CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed
Drug / intervention
estrogen replacement therapy +6 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00000555
NCT00000555Phase 3Completed
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Women's Angiographic Vitamin and Estrogen Trial (WAVE)

National Heart, Lung, and Blood Institute (NHLBI)·interventional·Posted Oct 28, 1999·Updated Jul 12, 2016

In Brief

A Phase 3 clinical trial evaluating estrogen replacement therapy, estrogens, conjugated, and 5 other interventions for Cardiovascular Diseases and 5 related conditions. Completed.

Detailed Summary

To assess whether hormonal replacement therapy and/or antioxidant treatment would stabilize or inhibit progression, and induce regression of coronary plaques. The mechanisms by which these treatments modified atherosclerosis in women were also explored.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases, Myocardial Ischemia, Postmenopause
Countries--
Collaborators--

Timeline

Phase 3CompletedFinished
19961997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 28, 1999
Enrollment StartAug 1, 1996
Study CompletionMay 1, 2003
TodayJul 2, 2026
Posted 26.7 years ago

Interventions

estrogen replacement therapydrug

estrogens, conjugateddrug

progesteronedrug

hormone replacement therapydrug

supplementation, fooddrug

ascorbic aciddrug

vitamin edrug