At a glance
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The Evaluation of Women With Perimenopause-Related Mood and Behavioral Disorders
In Brief
An observational study for Mood Disorder. Completed, enrolled 1,158 participants across 1 site.
Signals
Detailed Summary
The purpose of this study is to investigate mood and behavior changes in the time period surrounding and including menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies. Controversy exists regarding the relationship between estrogen and progesterone (gonadal steroid) changes and midlife-onset depression. This study will examine the role of gonadal steroids in perimenopausal mood and behavioral disorders. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to identify correlates of the occurrence of depression. Participants with depressive symptoms may also participate in companion studies that will test the antidepressant efficacy of phytoestrogens and selective estrogen receptor modulators (SERMS). A group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause in an effort to confirm the association of depression onset with changes in reproductive endocrine functioning.
Study Details
Timeline
Arms & Interventions
The purpose of this protocol is to allow for the careful screening of healthy volunteers for participation in research protocols.
The purpose of this protocol is to allow for the careful screening of patients for participation in research protocols.