At a glance
ClinicalIndex Comparison Record- ✓Age ≥2 years
- ✓Suspected or established inherited urologic malignancy with known disease gene (VHL, HPRC)
- ✓Suspected or established inherited urologic malignancy with unknown disease gene (Type II papillary renal cancer, clear cell renal carcinoma, renal oncocytoma, chromophobe renal carcinoma, Birt Hogg Dube)
- ✓Urologic malignant disease of suspected genetic etiology, including families with multiple affected individuals
None specified.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders
In Brief
An observational study for Kidney Cancer and 4 related conditions. Currently recruiting, targeting 5,000 participants across 1 site.
Detailed Summary
We will investigate the clinical manifestations and molecular genetic defects of heritable urologic malignant disorders. Families with urologic malignancy with known or suspected genetic basis will be enrolled. Affected individuals or individuals suspected of having a germline urologic malignant disorder will undergo periodic clinical assessment and genetic analyses for the purpose of: 1) definition and characterization of phenotype, 2) determination of the natural history of the disorder, and 3) genotype/phenotype correlation. Genetic linkage studies may be performed in situations in which the genetic basis of the disorder has not been elucidated.