At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A RANDOMIZED TRIAL COMPARING PREOPERATIVE DOXORUBICIN (ADRIAMYCIN)/CYCLOPHOSPHAMIDE (AC) TO PREOPERATIVE AC FOLLOWED BY PREOPERATIVE DOCETAXEL (TAXOTERE) AND TO PREOPERATIVE AC FOLLOWED BY POSTOPERATIVE DOCETAXEL IN PATIENTS WITH OPERABLE CARCINOMA OF THE BREAST
In Brief
A Phase 3 clinical trial evaluating Cyclophosphamide, Docetaxel, and 2 other interventions for Breast Cancer. Completed, enrolled 2,411 participants across 145 sites in 2 countries.
Detailed Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if chemotherapy given before surgery is more effective with or without docetaxel given before or after surgery for breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy using doxorubicin and cyclophosphamide with or without docetaxel in treating women who have stage II or stage III breast cancer.
Study Details
Timeline
Interventions
600 mg/m2 IV every 21 days for 4 cycles
100 mg/m2 IV every 21 days for 4 cycles
60 mg/m2 IV every 21 days fo 4 cycles
20 mg p.o. once daily for 5 years starting on day 1 of ther first AC cycle