At a glance
ClinicalIndex Comparison Record- ✓Histologically proven previously untreated classical Hodgkin's lymphoma
- ✓Locally extensive (Stage I-IIA/B with massive mediastinal adenopathy) or Advanced (Stage III or IV) disease
- ✓Measurable or evaluable disease
- ✓Age ≥16 years
- ✕Pregnant or nursing women
- ✕Prior radiotherapy
- ✕Prior chemotherapy
- ✕HIV positive
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Phase III Trial of ABVD Versus Stanford V (+/-) Radiation Therapy in Locally Extensive and Advanced Stage Hodgkin's Disease
In Brief
A Phase 3 clinical trial evaluating Doxorubicin, Bleomycin, and 8 other interventions for Lymphoma. Completed, enrolled 854 participants across 539 sites in 3 countries.
Detailed Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining more than one drug with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work, with or without radiation therapy, in treating patients with Hodgkin's lymphoma.
Study Details
Timeline
Interventions
given IV
given IV
given IV
given IV
given IV
given IV
given IV
taken orally
given IV