At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed supratentorial grade IV astrocytoma (glioblastoma multiforme)
- ✓Measurable or non-measurable tumor on post-operative, pretreatment MRI/CT within 2 weeks of starting treatment
- ✓No prior radiation therapy, chemotherapy, hormonal therapy, immunotherapy, biologic agents, immunotoxins, immunoconjugates, antisense, peptide receptor antagonists, interferons, interleukins, TIL, LAK, or gene therapy for brain tumor (glucocorticoids allowed)
- ✓Recovered from immediate post-operative period and maintained on stable steroid regimen (no increase for last 5 days)
- ✕Prior therapy for brain tumor except surgery
- ✕Prior treatment with antineoplastic agents, including CAI
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase II Clinical and Pharmacologic Study of Radiation Therapy and CAI (Carboxy-Amido Triazole) in Adults With Newly Diagnosed Glioblastoma Multiforme
In Brief
A Phase 2 clinical trial evaluating radiation therapy, carboxyamidotriazole, and 1 other intervention for Adult Giant Cell Glioblastoma and 2 related conditions. Completed, enrolled 55 participants across 8 sites.
Detailed Summary
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. Phase II trial to study the effectiveness of carboxyamidotriazole plus radiation therapy in treating patients who have newly diagnosed supratentorial glioblastoma multiforme.
Study Details
Timeline
Interventions
Undergo radiotherapy
Given orally
Correlative studies