At a glance
ClinicalIndex Comparison Record- ✓Newly diagnosed disseminated lymphoblastic lymphoma or localized lymphoblastic lymphoma
- ✓Stage III or IV disease
- ✓Less than 25% tumor cells in the bone marrow
- ✓Age 1 to 30 years
- ✕Prior treatment except intrathecal cytarabine (if protocol therapy begins within 72 hours) and emergency therapy for airway obstruction/superior vena cava syndrome
- ✕No prior therapy except emergency treatment of airway obstruction and/or superior vena cava syndrome
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Randomized Phase III Study for the Treatment of Newly Diagnosed Disseminated Lymphoblastic Lymphoma or Localized Lymphoblastic Lymphoma
In Brief
A Phase 3 clinical trial evaluating asparaginase, cyclophosphamide, and 11 other interventions for Lymphoma. Completed, enrolled 393 participants across 176 sites in 5 countries.
Detailed Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for lymphoblastic lymphoma. PURPOSE: This randomized phase III trial is studying different regimens of combination chemotherapy to compare how well they work in treating children or adolescents with newly diagnosed stage III or stage IV lymphoblastic lymphoma.
Study Details
Timeline
Interventions
Given IV
Given IV
Given IV
Given IV
Given IV
Given IV
Given IV
Given IV
Given IV
Given IV
Given PO
Given IV