At a glance

ClinicalIndex Comparison Record

N/ACompleted· 2,502 enrolled

Drug / intervention

Carotid Endarterectomy (CEA) +1 moreprocedure

Likely dose

Not stated in record

Key inclusion· 2

✓Symptomatic patients with recent TIA or non-disabling stroke with carotid stenosis ≥50% by angiography, or ≥70% by ultrasound, CTA, or MRA
✓Asymptomatic patients with no recent neurological events (≥6 months prior) with carotid stenosis ≥60% by angiography, or ≥70% by ultrasound, or ≥80% by CTA or MRA

Key exclusion· 2

✕Chronic atrial fibrillation and/or anticoagulation, or episodic atrial fibrillation within the last 6 months
✕Conditions that interfere with endpoint evaluation, completion of CEA or CAS, or affect likelihood of survival for the 4-year study period

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT00004732N/ACompleted

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Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

Rutgers, The State University of New Jersey·interventional·Posted Feb 28, 2000·Updated May 17, 2017

In Brief

A clinical study evaluating Carotid Endarterectomy (CEA) and Carotid Artery Stenting (CAS) for Atherosclerosis and 4 related conditions. Completed, enrolled 2,502 participants across 115 sites in 2 countries.

Detailed Summary

The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack) or a mild stroke within the past 6 months (symptomatic) and in those patients who have not had any symptoms within the past 6 months (asymptomatic).

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsAtherosclerosis, Stroke, Carotid Stenosis, Cerebral Infarction, Myocardial Infarction

CountriesCanada, United States

CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS), University of Alabama at Birmingham

Timeline

N/ACompletedFinished

2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

First PostedFeb 2000

Enrollment StartDec 2000

Primary CompletionFeb 2011

Study CompletionDec 2016

TodayJul 2026

First PostedFeb 28, 2000

Enrollment StartDec 1, 2000

Primary CompletionFeb 1, 2011

Study CompletionDec 1, 2016

TodayJul 2, 2026

Enrollment to primary: 10.2 yearsPosted 26.3 years ago

Interventions

Carotid Endarterectomy (CEA)procedure

CEA involves a neck incision and physical removal of the plaque from the inside of the carotid artery.

Carotid Artery Stenting (CAS)device

CAS involves insertion of a catheter or tube into an artery in the groin and then threading the catheter through the arteries of the body to the location of the plaque within the carotid artery in the neck. A stent is then placed to cover the plaque and hold the artery open. Participants randomized to this arm of the trial were treated using the RX Acculink Carotid Stent with or without the RX Accunet Embolic Protection Device.