At a glance
ClinicalIndex Comparison Record- ✓Type 2 diabetes mellitus
- ✓Overweight with BMI ≥25 kg/m² (≥27 kg/m² if on insulin)
- ✓Blood pressure <160/100 mmHg
- ✓HbA1c ≤11%
- ✕Schizophrenia, other psychotic disorders, or bipolar disorder
- ✕Hospitalization for depression in past 6 months
- ✕Alcohol or substance abuse within past 12 months or >14 alcoholic drinks per week
- ✕Cardiovascular event (heart attack or procedure) within past 3 months
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Look AHEAD: Action for Health in Diabetes
In Brief
A clinical study evaluating Lifestyle Intervention and Diabetes Support and Education for Diabetes and 5 related conditions. Completed, enrolled 5,145 participants across 18 sites.
Detailed Summary
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss. The study will investigate the effects of the intervention on heart attacks, stroke and cardiovascular-related death in individuals with type 2 diabetes who are also overweight or obese.
Study Details
Timeline
Interventions
The lifestyle intervention is implemented with individual supervision and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. It is implemented during a four-year period with the most intensive application during the first year, less frequent attention during the next three years, and a minimum of twice yearly contacts during an extended follow-up period. To help participants achieve and maintain weight loss, a variety of diet strategies (e.g. prepared meals and liquid formula), exercise strategies, and optional weight loss medications are utilized based on a preset algorithm and participant progress.
Participants assigned to diabetes support and education are offered three sessions each year in diabetes management and social support.