At a glance
ClinicalIndex Comparison Record- ✓Left ventricular ejection fraction less than 35% documented by echocardiogram, left ventriculogram, CMR, or gated SPECT
- ✓Coronary artery disease anatomy suitable for surgical revascularization
- ✓No left main coronary artery disease (≥50% stenosis) for patients in the medical therapy only arm
- ✓Canadian Cardiovascular Society angina class less than III for patients in the medical therapy only arm
- ✕Recent acute myocardial infarction judged to be an important cause of left ventricular dysfunction
- ✕Cardiogenic shock within 72 hours of randomization, defined by need for intraaortic balloon support or intravenous inotropic support
- ✕History of more than one prior coronary artery bypass operation
- ✕Aortic valvular heart disease clearly indicating need for aortic valve repair or replacement
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Surgical Treatment for Ischemic Heart Failure (STICH)
In Brief
A Phase 3 clinical trial evaluating CABG surgery plus MED, Active Medication Alone, and 1 other intervention for Cardiovascular Diseases and 3 related conditions. Completed, enrolled 2,136 participants across 1 site.
Detailed Summary
This study will compare medical therapy with coronary bypass surgery and/or surgical ventricular reconstruction for patients with congestive heart failure and coronary artery disease (CAD).
Study Details
Timeline
Interventions
CABG plus standard medication management for Coronary Artery Disease
Standard medication for coronary artery disease and heart failure management.
H02: the experimental arm receives active medical therapy and CABG and surgical ventricular restoration whereas the control group receives active medical therapy and CABG; for H01: the experimental arm receives active medical therapy and CABG whereas the control group receives active medical therapy alone