At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed stage III or IV ovarian epithelial, fallopian tube, or primary peritoneal cancer treated with only 1 prior first-line chemotherapy regimen (platinum/taxane-based)
- ✓Clinically and radiologically without evidence of measurable and nonmeasurable disease
- ✓Biochemical recurrence: CA 125 normalized during first-line therapy then rose to exceed twice the upper limit of normal
- ✓CA 125 <100 U/mL must be confirmed a second time within 4 weeks; CA 125 ≥100 U/mL may be entered without confirmatory measurement
- ✕No prior immunotherapy, biological response modifiers, or antiangiogenic agents
- ✕No prior or concurrent tamoxifen or other selective estrogen receptor modulators
- ✕No grade 2 or greater sensory or motor neuropathy
- ✕No other malignancy within past 5 years except nonmelanoma skin cancer or carcinoma in situ
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Study Of Tamoxifen Versus Thalidomide (NSC# 66847) In Patients With Biochemical-Recurrence-Only Epithelial Ovarian Cancer, Cancer Of The Fallopian Tube, And Primary Peritoneal Carcinoma After First Line Chemotherapy
In Brief
A Phase 3 clinical trial evaluating tamoxifen citrate, thalidomide, and 1 other intervention for Fallopian Tube Cancer and 4 related conditions. Completed, enrolled 139 participants across 1 site.
Detailed Summary
Randomized phase III trial to compare the effectiveness of tamoxifen with that of thalidomide in treating women who have recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer. Estrogen can stimulate the growth of some types of cancer cells. Hormone therapy using tamoxifen may fight cancer by blocking the uptake of estrogen. Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. It is not yet known whether thalidomide is more effective than tamoxifen in treating ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.
Study Details
Timeline
Interventions
Given orally
Given orally
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