CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 39 enrolled
Drug / intervention
Clozapine +1 moredrug
Likely dose
Not stated in record
Key inclusion· 7
  • ✓Diagnosis of schizophrenia per DSM-IV criteria
  • ✓Illness duration of 2 years or more
  • ✓Resistance to at least 2 prior antipsychotics
  • ✓Documented clozapine resistance
Key exclusion· 7
  • ✕Schizoaffective disorder or bipolar disorder
  • ✕Current affective episode
  • ✕ECT within the past 6 months
  • ✕History of epilepsy or severe neurological/systemic disorder affecting cognition, behavior, or mental status

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00042224
NCT00042224Phase 2Completed
CompareCT.gov

ECT in Clozapine Refractory Schizophrenia

Northwell Health·interventional·Posted Jul 26, 2002·Updated May 15, 2017

In Brief

A Phase 2 clinical trial evaluating Electroconvulsive Therapy (ECT) and Clozapine for Schizophrenia. Completed, enrolled 39 participants across 1 site.

Detailed Summary

This study will evaluate electroconvulsive therapy (ECT) in patients who have not responded adequately to clozapine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSchizophrenia
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 2CompletedFinished
200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 26, 2002
Enrollment StartDec 1, 2000
Primary CompletionJul 1, 2008
TodayJul 2, 2026
Enrollment to primary: 7.6 yearsPosted 23.9 years ago

Interventions

Electroconvulsive Therapy (ECT)procedure

ECT will be used to augment clozapine in schizophrenic patients who continue to have psychotic symptoms despite optimal treatment with clozapine.

Clozapinedrug

Patients with psychotic symptoms will receive clozapine