CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 156 enrolled
Drug / intervention
Sertraline +3 moredrug
Likely dose
Sertraline and venlafaxine doses not specified; supportive-expressive psychotherapy providedAI-extracted
Key inclusion· 1
  • ✓Diagnosis of Major Depressive Disorder
Key exclusion· 2
  • ✕Psychotic or bipolar disorder diagnosis
  • ✕Substance dependence in the last 6 months

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00043550
NCT00043550Phase 3Completed
CompareCT.gov

Efficacy of Dynamic Therapy Versus Selective Serotonin Reuptake Inhibitor for Depression

University of Pennsylvania·interventional·Posted Aug 12, 2002·Updated Jun 2, 2017

In Brief

A Phase 3 clinical trial evaluating Supportive Expressive Therapy, Sertraline, and 2 other interventions for Depression. Completed, enrolled 156 participants across 1 site.

Detailed Summary

This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 3CompletedFinished
20022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 12, 2002
Enrollment StartNov 1, 2001
Primary CompletionJun 1, 2009
TodayJul 2, 2026
Enrollment to primary: 7.6 yearsPosted 23.9 years ago

Interventions

Supportive Expressive Therapybehavioral

The aim of supportive-expressive psychotherapy is to help patients understand the causes of relationship conflicts in the context of a supportive relationship.

Sertralinedrug

Participants will receive sertraline.

Pill Placebodrug

Participants will receive a pill placebo.

Venlafaxinedrug

Participants will receive venlafaxine.