At a glance
ClinicalIndex Comparison Record- ✓Age 55 to 74 years
- ✓30 or more pack-years of cigarette smoking history
- ✓Former smokers must have quit within the previous 15 years
- ✓Ability to lie on back with arms raised over head for imaging
- ✕History of lung cancer
- ✕Prior removal of any portion of lung, excluding needle biopsy
- ✕Requirement for home oxygen supplementation
- ✕Cancer (other than nonmelanoma skin cancer or carcinoma in situ) in past 5 years
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
National Lung Screening Trial A Randomized Trial Comparing Low-dose Helical CT With Chest Xray for Lung Cancer
In Brief
A Phase 3 clinical trial evaluating low-dose helical computed tomography and chest radiography for Lung Cancer. Completed, enrolled 53,454 participants across 33 sites.
Detailed Summary
RATIONALE: Effective screening tests should help doctors detect lung cancer early and plan curative treatment. It is not yet known whether low-dose helical computed tomography (LDCT) screening is more effective than chest radiography (CXR) screening in reducing death from lung cancer. PURPOSE: Randomized clinical trial to compare the effectiveness of LDCT scan with that of CXR in screening individuals who are at high risk for developing lung cancer.
Study Details
Timeline
Interventions
A LDCT is a computerized tomography image with low-dose technique without contrast. The scan is done from the neck to the diaphragm in one breath-hold.
The chest x-ray in this study was a single posterior-anterior film done with the participant upright.