At a glance
ClinicalIndex Comparison Record- ✓Age 18-50 years old
- ✓Good physical health based on medical history, clinical MRI, and physical exam
- ✓For healthy subjects: good psychiatric health per SCID; for patients: primary diagnosis of GAD, panic disorder, SAD, PTSD, specific phobia, or major depression
- ✓Able to understand procedures and provide written informed consent
- ✕Clinically significant organic disease (e.g., cardiovascular disease)
- ✕Clinically significant abnormalities on physical examination
- ✕Medical conditions increasing fMRI risk (e.g., pacemaker, metallic foreign body in eye)
- ✕History of organic mental disorders, seizure, or mental retardation
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
fMRI Investigation of Explicit Cue and Contextual Fear
In Brief
A clinical study evaluating Shock device and Acoustic startle for Anxiety Disorders and Fear. Completed, enrolled 1,080 participants across 1 site.
Detailed Summary
The purpose of this study is to use brain imaging technology to investigate brain changes in people exposed to predictable versus unpredictable unpleasant stimuli. Unpleasant events that can be predicted evoke a response of fear, whereas unpredictable, unpleasant stimuli cause chronic anxiety not associated with a specific event. Information gained from this study may help in the development of more effective treatments for anxiety disorders. When confronted with fearful events, people eventually develop fear of specific cues that were associated with these events as well as to the environmental context in which the fearful event occurred. Evidence suggests that cued fear and contextual fear model different aspects of anxiety. However, studies that examine the way the brain affects expression of contextual fear have not been conducted. This study will use magnetic resonance imaging (MRI) or Magneto-encephalography (MEG) to compare the brain activity underlying fear brought on by predictable and unpredictable aversive stimuli.
Study Details
Timeline
Interventions
A participant could receive a shock or not receive as shock
Acoustic startle for MEG only