CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 73 enrolled
Drug / intervention
Citalopram +2 moredrug
Likely dose
Citalopram ≥40 mg/day or St. John's Wort ≥900 mg/dayAI-extracted
Key inclusion· 5
  • ✓Minor depression symptoms persisting for at least 6 months
  • ✓Meets partial DSM-IV criteria for major depressive disorder (one 'A' criterion plus ≥1 other symptom, or both 'A' criteria)
  • ✓HAM-D-17 score between 10 and 17 (inclusive)
  • ✓Functional impairment demonstrated by GAF score <70 or SF-36 social/emotional role functioning ≤75% or ≤67%
Key exclusion· 12
  • ✕Major depressive disorder or dysthymia within the past year, or current partial remission of MDD
  • ✕Prior adequate treatment course (≥12 weeks) with citalopram ≥40 mg/day or St. John's Wort ≥900 mg/day in current episode
  • ✕History of intolerance or nonresponse to citalopram ≥40 mg/day or St. John's Wort ≥900 mg/day for ≥12 weeks
  • ✕Unstable medical illness (cardiovascular, hepatic, renal, respiratory, endocrine, neurologic, hematologic disease)

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00048815
NCT00048815N/ACompleted
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Pharmacotherapy for Minor Depression

Massachusetts General Hospital·interventional·Posted Nov 13, 2002·Updated May 11, 2018

In Brief

A clinical study evaluating Citalopram, St. John's Wort, and 1 other intervention for Depression. Completed, enrolled 73 participants across 3 sites.

Detailed Summary

This 6-month study will compare the effectiveness of citalopram (Celexa®), hypericum (St. John's Wort), and placebo for the treatment of minor depression.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH), Office of Dietary Supplements (ODS)

Timeline

N/ACompletedFinished
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 13, 2002
Enrollment StartFeb 1, 2003
Primary CompletionApr 1, 2007
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 23.6 years ago

Interventions

Citalopramdrug

Established Selective Serotonin Reuptake Inhibitor antidepressant

St. John's Wortdrug

Natural extract from the St. John's Wort plant.

Placebosdrug

Placebo pill