At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed nasopharyngeal cancer, stage II-IVB, newly diagnosed
- ✓Age 18 and over
- ✓Karnofsky performance status 60-100%
- ✓No distant metastases
- ✕Prior chemotherapy for this diagnosis
- ✕Prior radiotherapy for this diagnosis
- ✕Prior radiotherapy to the head and neck region
- ✕Other active malignancy within past 3 years (except nonmelanoma skin cancer or cervical carcinoma in situ)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase I/II Study of Dose-Painting Using Intensity Modulated Radiation Therapy Plus Chemotherapy in Patients With Stage II-IVB Nasopharyngeal Carcinoma
In Brief
A Phase 2 clinical trial evaluating cisplatin, fluorouracil, and 2 other interventions for Head and Neck Cancer. Completed, enrolled 25 participants across 1 site.
Detailed Summary
RATIONALE: Radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining high-dose radiation with chemotherapy may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of combining high-dose radiation therapy with chemotherapy in treating patients who have newly diagnosed stage II, stage III, or stage IV nasopharyngeal cancer.