At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of anxiety disorder (GAD, SAD, panic disorder, or specific phobia) or mood disorder (MDD or bipolar disorder) for patients
- ✓Able to give written informed consent
- ✓Speaks English fluently
- ✕Current alcohol or substance abuse
- ✕History of alcohol or substance dependence within 6 months prior to screening
- ✕Currently pregnant
- ✕History of psychotic disorder or bipolar disorder (for healthy controls); past history of psychotic disorder or bipolar disorder (for patients with anxiety/mood disorders)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Predictability and Aversive Expectancies in Anxiety and Depressive Disorders
In Brief
A clinical study evaluating Threat of shock for Anxiety Disorders. Completed, enrolled 921 participants across 1 site.
Detailed Summary
Fear and anxiety are normal responses to a threat. However, anxiety is considered abnormal when the response to the threat is excessive or inappropriate. This study will examine changes in the body and brain that occur during unpleasant learning experiences in healthy volunteers with high, moderate, and low levels of anxiety. A high degree of generalized anxiety is a component of many anxiety disorders and is regarded as a marker of vulnerability for these disorders. People with anxiety disorders and individuals with high degrees of anxiety have inappropriate expectations of unpleasant events. This study will investigate the development of expecting unpleasant events in healthy volunteers with varying degrees of anxiety using aversive conditioning models. A later phase of the study will enroll participants with anxiety disorders and compare their responses to those of healthy volunteers. Patients who meet criteria for an anxiety disorder, and healthy volunteers who have no history of psychiatric or major medical illness will be enrolled in this study. Volunteers will come to the NIH Clinical Center three times for outpatient testing....
Study Details
Timeline
Interventions
During threat, a participant could receive a shock. During safe, a participant could not receive as shock. Participants selected their highest tolerable level of shock.