At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 491 enrolled
Drug / intervention
Medication Only +2 moredrug
Likely dose
Not stated in record
Key inclusion· 4
- ✓Major depressive episode
- ✓Depressive symptoms lasting more than 2 years without remission
- ✓Hamilton Depression Scale (HAM-D) score greater than 20
- ✓Fluent in English
Key exclusion· 8
- ✕Psychotic disorders, bipolar disorder, PTSD, OCD, or eating disorder
- ✕Serious, unstable, or terminal medical condition
- ✕Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder
- ✕Previous treatment with CBASP
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
CBASP Augmentation for Treatment of Chronic Depression
In Brief
A Phase 4 clinical trial evaluating Brief Supportive Psychotherapy, CBASP, and 1 other intervention for Depression and Depressive Disorder. Completed, enrolled 491 participants across 8 sites.
Detailed Summary
This 24-week study, with a 12-month follow up period, will compare the effectiveness of antidepressant medication alone to the combination of psychotherapy and antidepressant medication in patients with chronic depression.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Depressive Disorder
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)
Timeline
Phase 4CompletedFinished
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 2003
First PostedApr 2003
Primary CompletionMar 2007
TodayJul 2026
First PostedApr 7, 2003
Enrollment StartApr 1, 2003
Primary CompletionMar 1, 2007
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 23.2 years ago
Interventions
Brief Supportive Psychotherapybehavioral
brief supportive psychotherapy
CBASPbehavioral
psychotherapy developed for chronic depression
Medication Onlydrug
antidepressant medication