At a glance
ClinicalIndex Comparison Record- ✓Recurrent or chronic major depressive disorder
- ✕Current diagnosis of psychotic affective disorder
- ✕History of nonaffective psychotic disorder
- ✕Substance dependence in the last three months requiring detoxification
- ✕Schizotypal, antisocial, or borderline personality disorder
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Prevention of Recurrence in Depression With Drugs and CT
In Brief
A Phase 4 clinical trial evaluating Cognitive Therapy and Medications for Depression. Completed, enrolled 452 participants across 3 sites.
Detailed Summary
This study will determine whether the addition of Cognitive Therapy (CT) to antidepressant medication (ADM) enhances treatment for depression. This study will also test whether the addition of CT to ADM will prevent recurrences of depression after therapy is over.
Study Details
Timeline
Interventions
CT sessions occur weekly during acute treatment and monthly during continuation. Acute treatment may last up to 18 months. Remitted patients are continued on medication for up to 36 months from initial randomization until they meet criteria for recovery. At recovery, patients receiving combined treatment discontinue CT.
Antidepressant medication is distributed as clinically indicated with augmentation and ancillary medications as needed. Acute treatment may last up to 18 months. Remitted patients are continued on medication for up to 36 months from the point of initial randomization until they meet criteria for recovery. All recovered patients are randomized a second time to either maintenance medication or medication withdrawal. Patients are then monitored over 36 months to ascertain risk for recurrence of depressive symptoms.