At a glance
ClinicalIndex Comparison Record- ✓Newly diagnosed advanced anaplastic large cell lymphoma
- ✓CD30+ (Cluster of differentiation antigen 30 positive)
- ✓Murphy stage III or IV
- ✓Age under 21 years
- ✕B-cell large cell lymphoma
- ✕Disease limited to the skin
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase III Trial of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma (ALCL) With Standard APO (Doxorubicin, Prednisone, Vincristine) Versus Consolidation With a Regimen Including Vinblastine
In Brief
A Phase 3 clinical trial evaluating doxorubicin hydrochloride, mercaptopurine, and 4 other interventions for Lymphoma. Completed, enrolled 129 participants across 159 sites in 5 countries.
Detailed Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known if combination chemotherapy with vinblastine is more effective than combination chemotherapy with vincristine in treating advanced anaplastic large cell lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens with either vinblastine or vincristine in treating patients who have newly diagnosed advanced anaplastic large cell lymphoma.
Study Details
Timeline
Interventions
Given IV
Given by mouth
Given IV and intrathecally
Given by mouth
Given IV
Given IV