At a glance
ClinicalIndex Comparison Record- ✓Histologically or cytologically confirmed small cell carcinoma of the lung
- ✓Limited disease: Stage I, II, IIIA, or IIIB confined to one hemithorax (excluding T4 with malignant pleural effusion or N3 contralateral disease)
- ✓Measurable or evaluable disease
- ✓Tumor must be encompassable by limited radiotherapy fields without significantly compromising pulmonary function
- ✕No pericardial or pleural effusions on chest x-ray
- ✕Prior complete tumor resection
- ✕Prior chemotherapy
- ✕Prior radiotherapy to the chest or bone marrow-rich areas (>75% of pelvic bone)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase II Study Of Accelerated High Dose Thoracic Irradiation With Concurrent Chemotherapy For Patients With Limited Small Cell Lung Cancer
In Brief
A Phase 2 clinical trial evaluating Cisplatin, Etoposide, and 1 other intervention for Lung Cancer. Completed, enrolled 72 participants across 104 sites.
Detailed Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cisplatin and etoposide together with radiation therapy works in treating patients with limited-stage small cell lung cancer.
Study Details
Timeline
Interventions
60 mg/m2 given intravenously. During RT, give on day 1 and day 22. After completion of RT, on days 43 and 64.
120 mg/m2 given intravenously. During RT, give on days 1-3, then days 22-24. After completion of RT, on days 43-45 and days 64-66.
Large field 28.8 Gy: 1.8 Gy per fraction, 5 days per week for 16 fractions. On days 23-26, BID: use anteroposterior and posteroanterior (AP/PA) fields in a.m. at 1.8 Gy per fraction; boost with 2nd treatment in p.m. at 1.8 Gy per fraction. Then off-cord boost, 1.8 Gy, BID, x last 5 days for a total dose of 61.2 Gy in 5 wks.