At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of locally advanced squamous cell carcinoma of the vulva, T3 or T4 stage (N0-3, M0)
- ✓Disease not amenable to surgical resection by standard radical vulvectomy
- ✓Previously untreated disease with no recurrent disease
- ✓GOG performance status 0–3
- ✕Vulvar melanoma or sarcoma
- ✕Gastrointestinal bleeding or severe gastrointestinal symptoms
- ✕Septicemia or severe infection
- ✕Other invasive malignancy within the past 5 years (except nonmelanoma skin cancer)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase II Trial of Radiation Therapy and Weekly Cisplatin Chemotherapy for the Treatment of Locally-Advanced Squamous Cell Carcinoma of the Vulva
In Brief
A Phase 2 clinical trial evaluating 3-Dimensional Conformal Radiation Therapy, Cisplatin, and 1 other intervention for Stage III Vulvar Cancer and 2 related conditions. Completed, enrolled 61 participants across 103 sites.
Detailed Summary
This phase II trial is studying how well giving radiation therapy together with cisplatin followed by surgery works in treating patients with locally advanced cancer of the vulva. Drugs used in chemotherapy such as cisplatin use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving chemotherapy with radiation therapy before surgery may shrink the tumor so it can be removed during surgery.
Study Details
Timeline
Interventions
Given IV