At a glance
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The Use of Recombinant Growth Hormone to Enhance T-Cell Production in Adults Infected With HIV-1
In Brief
A Phase 2 clinical trial evaluating Somatropin (recombinant human growth hormone) for HIV Infections. Completed, enrolled 22 participants across 1 site.
Detailed Summary
Growth hormone plays an important role in the development of the immune system. Studies suggest that growth hormone may promote growth of the thymus, a gland responsible for the production of important immune cells called T cells. Since these cells are lost during the course of HIV infection, it is possible that growth hormone treatment could help restore the immune system. This study will determine whether the administration of growth hormone can increase the size and function of the thymus and cause an increase in the number of new T cells in the blood of people infected with HIV. Study hypothesis: Growth hormone treatment will enhance T cell production in HIV infected adults.
Study Details
Timeline
Interventions
3.0mg sc daily for 6 months, followed by 1.5mg sc daily for 6 months. Dose stopped, held or reduced by study investigators as indicated by adverse events