At a glance
ClinicalIndex Comparison Record- ✓Unicentric and unifocal breast carcinoma with clinical, mammographic, ultrasonographic, or pathologic diagnosis
- ✓Largest tumor lesion ≤5 cm
- ✓Prior (preoperative) or planned (intraoperative) sentinel node biopsy required
- ✓At least 1 micrometastatic sentinel lymph node (≤2 mm) with no extracapsular extension
- ✕Paget's disease without invasive cancer
- ✕Suspicious manifestations of metastases that cannot be ruled out by imaging (skeletal pain of unknown cause, elevated alkaline phosphatase, bone scan hot spots)
- ✕Palpable axillary lymph nodes
- ✕Prior systemic therapy for breast cancer
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Trial Of Axillary Dissection Versus No Axillary Dissection For Patients With Clinically Node Negative Breast Cancer And Micrometastases In The Sentinel Node
In Brief
A clinical study evaluating Axillary lymph node dissection and No axillary lymph node dissection for Breast Cancer. Completed, enrolled 931 participants across 31 sites in 10 countries.
Detailed Summary
RATIONALE: Surgery to remove lymph nodes in the armpit in patients with sentinel lymph node micrometastases may remove cancer cells that have spread from tumors in the breast. It is not yet known whether surgery to remove the primary tumor is more effective with or without axillary lymph node dissection. PURPOSE: This randomized phase III trial is studying surgery and axillary lymph node dissection to see how well they work compared to surgery alone in treating women with node-negative breast cancer and sentinel lymph node micrometastases.
Study Details
Timeline
Interventions
Axillary lymph node dissection
Therapeutic conventional surgery