At a glance
ClinicalIndex Comparison Record- ✓Newly diagnosed B-precursor acute lymphoblastic leukemia
- ✓WBC ≥50,000/uL for ages 1-9 years
- ✓Any WBC for ages 10-30 years, OR patients with prior steroid therapy, OR patients with testicular disease
- ✓Must be eligible for and enrolled on classification study COG-AALL03B1
- ✕Down syndrome
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
High Risk B-Precursor Acute Lymphoblastic Leukemia (ALL)
In Brief
A Phase 3 clinical trial evaluating Cyclophosphamide, Cytarabine, and 11 other interventions for Acute Lymphoblastic Leukemia and 2 related conditions. Completed, enrolled 3,154 participants across 234 sites in 5 countries.
Detailed Summary
This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy. This trial is also studying methotrexate and leucovorin calcium to see how well they work compared to methotrexate alone during maintenance therapy in treating patients with newly diagnosed acute lymphoblastic leukemia (ALL). Drugs used in chemotherapy, such as dexamethasone, prednisone, methotrexate, and leucovorin calcium, work in different ways to stop cancer cells from dividing so they stop growing or die. Giving more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating acute lymphoblastic leukemia.
Study Details
Timeline
Interventions
Given IV
Given IT, SC, or IV
Given IV
Given PO or IV
Given IV
Given IV
Given PO
Given IT or IV
Given IM
Given PO or IV
Undergo radiation therapy
Given PO
Given IV