At a glance
ClinicalIndex Comparison Record- ✓Histologically or cytologically confirmed malignancy
- ✓Painful bone metastases confirmed by imaging (X-ray, bone scan, CT, or MRI)
- ✓Baseline pain score ≥2/10 on Brief Pain Inventory
- ✓Pain from previously irradiated metastases, not from new/progressive disease elsewhere
- ✕Clinical or radiological evidence of pathological fractures at target site
- ✕High-risk lytic lesions (>3 cm or >50% cortical erosion) in extremities if patient is surgical candidate
- ✕Clinical or radiological evidence of spinal cord compression at target site
- ✕More than 1 prior course of radiotherapy to target site
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase III International Randomized Trial Of Single Versus Multiple Fractions For Re-Irradiation Of Painful Bone Metastases
In Brief
A clinical study evaluating radiation therapy for Metastatic Cancer and Pain. Completed, enrolled 850 participants across 12 sites.
Detailed Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether single-fraction (single-dose) re-irradiation therapy is as effective as multiple-fraction (many small doses of radiation therapy) re-irradiation therapy in relieving bone pain caused by bone metastases. PURPOSE: This randomized phase III trial is studying single-dose radiation therapy to see if it works as well as multiple-dose radiation therapy in treating patients previously irradiated with painful bone metastases.
Study Details
Timeline
Interventions
Given in a single fraction or multiple fractions