CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 98 enrolled
Drug / intervention
Dextrose Prolotherapy +2 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00085722
NCT00085722Phase 2Completed
CompareCT.gov

The Efficacy of Prolotherapy in Osteoarthritic Knee Pain

University of Wisconsin, Madison·interventional·Posted Jun 16, 2004·Updated Feb 15, 2019

In Brief

A Phase 2 clinical trial evaluating Dextrose Prolotherapy, Saline Prolotherapy, and 1 other intervention for Osteoarthritis. Completed, enrolled 98 participants across 2 sites.

Detailed Summary

The purpose of this study is to determine whether prolotherapy (PrT), a therapy based on injection of a sugar solution in and around the knee, can decrease pain and disability from knee osteoarthritis (OA).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteoarthritis
CountriesUnited States
CollaboratorsNational Center for Complementary and Integrative Health (NCCIH)

Timeline

Phase 2CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJun 16, 2004
Enrollment StartJul 1, 2004
Primary CompletionNov 1, 2008
Study CompletionMay 1, 2016
TodayJul 2, 2026
Enrollment to primary: 4.3 yearsPosted 22.0 years ago

Interventions

Dextrose Prolotherapyprocedure

Injection procedure: 50% dextrose is diluted with .9% 'normal' saline and 1% lidocaine to achieve 15% dextrose for ligament injections and 25% dextrose for intra-articular injection.

Saline Prolotherapyprocedure

7 mL 9% 'normal' saline and 3mL 1% lidocaine

At-home physical therapy exercise groupother

Subjects in the at-home physical therapy exercise group will receive a patient information pamphlet about knee osteoarthritis and conservative care instructions for standard at-home physical therapy exercises