At a glance
ClinicalIndex Comparison Record- ✓Histologically or cytologically confirmed squamous cell carcinoma of the head and neck
- ✓Stage III or IV disease without distant metastases
- ✓Primary tumor sites: oral cavity (without mandible invasion), oropharynx, hypopharynx, or larynx
- ✓Age over 18 years
- ✕Prior chemotherapy
- ✕Prior radiotherapy
- ✕Prior surgery for this cancer (except biopsy)
- ✕Symptomatic peripheral neuropathy greater than grade 2
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Phase III Comparing Sequential Therapy With TPF/Chemoradiation (ST) To Cisplatinum-Based Chemoradiotherapy [PARADIGM TRIAL]
In Brief
A Phase 3 clinical trial evaluating carboplatin, cisplatin, and 2 other interventions for Head and Neck Cancer. Completed, enrolled 145 participants across 15 sites in 2 countries.
Detailed Summary
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, fluorouracil, and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. It is not yet known which regimen of chemotherapy and radiation therapy is most effective in treating head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two different regimens of chemotherapy and radiation therapy in treating patients who have stage III or stage IV head and neck cancer.
Study Details
Timeline
Interventions
Given IV
Given IV
Given IV
Given IV