CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 56 enrolled
Drug / intervention
Exposure to relaxant and stimulant odorsbehavioral
Likely dose
100 ml essential oil or distilled water on cotton ball applied topically between nose and upper lipAI-extracted
Key inclusion· 1
  • ✓Healthy adults with normal sense of smell
Key exclusion· 10
  • ✕Treatment with medication affecting immune or endocrine systems
  • ✕Chronic health problems affecting immune or endocrine systems
  • ✕Allergy to perfume or cosmetics
  • ✕Problems with sense of smell

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00097253
NCT00097253Phase 1Completed
CompareCT.gov

Psychoneuroimmunology and Mind-Body Medicine: Olfaction, Mood, and Physiological Responses

National Center for Complementary and Integrative Health (NCCIH)·interventional·Posted Nov 22, 2004·Updated Feb 18, 2010

In Brief

A Phase 1 clinical trial evaluating Exposure to relaxant and stimulant odors for Stress and 2 related conditions. Completed, enrolled 56 participants across 1 site.

Detailed Summary

The purpose of this study is to examine the body's response to relaxing and stimulating fragrances commonly used in aromatherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStress, Anxiety, Depression
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 22, 2004
Enrollment StartAug 1, 2005
Primary CompletionMar 1, 2006
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 21.6 years ago

Interventions

Exposure to relaxant and stimulant odorsbehavioral

A yellow-tinted cotton ball containing 100 ml of the essential oil or distilled water was taped between the nose and upper lip on top of a piece of surgical tape; use of the barrier tape avoided percutaneous absorption . This method provided continuous and uniform exposure across subjects that would not have been possible with ambient room inhalation, and helped maintain experimenter blindness.