At a glance
ClinicalIndex Comparison Record- ✓Radiological or established histological diagnosis of high-grade glioma, CNS lymphoma, or brain metastases
- ✓Previously untreated subjects must have a visible lesion on imaging
- ✓Post-treatment subjects with radiographic abnormalities that may or may not represent recurrent tumor are eligible
- ✓Pre-imaging radiological scans within 24 hours to 16 weeks prior to study entry
- ✕Clinical signs of uncal herniation (acute pupillary enlargement, rapidly developing motor changes, or rapidly decreasing consciousness)
- ✕Allergy or hypersensitivity to parenteral iron, dextran, iron-dextran, or iron-polysaccharide preparations
- ✕Pregnancy or lactation
- ✕Renal insufficiency with GFR <50
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
NCI-Sponsored Multi-Disciplinary Study for MR Imaging of Intravenous Superparamagnetic Crystalline Particle Ferumoxytol in Primary High-Grade Brain Tumors and/or Cerebral Metastases
In Brief
A clinical study evaluating 3 Tesla Magnetic Resonance Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, and 4 other interventions for Central Nervous System Lymphoma and 2 related conditions. Completed, enrolled 155 participants across 1 site.
Detailed Summary
This clinical trial studies magnetic resonance imaging (MRI) using a contrast imaging agent ferumoxytol (ferumoxytol non-stoichiometric magnetite) in improving viewing tumors in patients with high-grade brain tumors or cancer that has spread to the brain. Diagnostic procedures, such as MRI, may help find and diagnose brain tumors and find out how far the disease has spread. The contrast imaging agent ferumoxytol non-stoichiometric magnetite consists of small iron particles taken by the blood stream to the brain and to the area of the tumor. It may help visualize the blood flow going through the tumor better than the standard substance gadolinium-based contrast agent.
Study Details
Timeline
Interventions
Undergo 3T MRI
Undergo 3T DCE-MRI
Undergo 3T DSC-MRI
Given IV
Given IV
Undergo MRA