CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 42 enrolled
Drug / intervention
Gefitinib + Sunitinibdrug
Likely dose
Sunitinib and gefitinib (specific doses not stated in arms/interventions)AI-extracted
Key inclusion· 3
  • Histologically confirmed renal cell carcinoma with metastases
  • Measurable disease by imaging
  • No prior systemic therapy for metastatic RCC or failure of 1 prior immunotherapy
Key exclusion· 4
  • RCC without clear cell component (e.g., pure papillary, chromophobe)
  • History of or known brain metastases
  • Uncontrolled hypertension
  • Significant cardiac events within 12 months prior to study entry

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00113529
NCT00113529Phase 2Completed

A Phase 1/2 Safety And Pharmacokinetic Study Of SU011248 In Combination With Gefitinib (Iressa) In Patients With Metastatic Renal Cell Carcinoma

Pfizer·interventional·Posted Jun 9, 2005·Updated Aug 29, 2011

In Brief

A Phase 2 clinical trial evaluating Gefitinib + Sunitinib for Carcinoma, Renal Cell. Completed, enrolled 42 participants across 3 sites.

Detailed Summary

To assess the maximum tolerated dose and overall safety and tolerability of sunitinib \[SU011248\] administered in combination with gefitinib (Iressa) for the treatment of patients with metastatic renal cell carcinoma (Phase 1). To assess antitumor activity of the combination of gefitinib and sunitinib (Phase 2).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJun 9, 2005
Enrollment StartOct 1, 2004
Primary CompletionSep 1, 2007
Study CompletionOct 1, 2008
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 21.1 years ago

Interventions

Gefitinib + Sunitinibdrug

Until disease progression or unacceptable toxicity.