CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 487 enrolled
Drug / intervention
Dopamine infusion to brain dead organ donorsdrug
Likely dose
Dopamine infusion to brain dead organ donors 4µgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00115115
NCT00115115Phase 4Completed
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Prospective Randomized Trial to Evaluate the Efficacy of Donor Preconditioning With Dopamine on Initial Graft Function After Kidney Transplantation

Universitätsmedizin Mannheim·interventional·Posted Jun 21, 2005·Updated Apr 23, 2009

In Brief

A Phase 4 clinical trial evaluating Dopamine infusion to brain dead organ donors for Kidney Transplantation and ESRD. Completed, enrolled 487 participants across 1 site.

Detailed Summary

Donor pre-treatment with dopamine reduces injury to the kidney graft with consequences on the clinical performance immediately after transplantation: Donor dopamine reduces the requirement of dialysis post transplant, and results in renal function improvements. The purpose of the study is to investigate the potentially therapeutic impact of donor preconditioning with low dose dopamine in human renal transplant recipients from a brain dead donor.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsKidney Transplantation, ESRD
CountriesGermany
CollaboratorsEurotransplant International Foundation, Leiden, The Netherlands, Regional Organ Procurement Organization (DSO), Baden-Wuerttemberg, Germany, Regional Organ Procurement Organization (DSO), Bavaria, Germany, Novartis

Timeline

Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJun 21, 2005
Enrollment StartMar 1, 2004
Primary CompletionDec 1, 2007
Study CompletionMar 1, 2009
TodayJul 2, 2026
Enrollment to primary: 3.8 yearsPosted 21.0 years ago

Interventions

Dopamine infusion to brain dead organ donorsdrug

Dopamine infusion administered at a dosage of 4µg/kg/min starting after brain death has been proven until to surgical procurement of the kidneys