At a glance
ClinicalIndex Comparison Record- ✓Confirmed diagnosis of relapsing-remitting multiple sclerosis
- ✓Diagnosed depressive disorder
- ✓Moderate depressive symptoms (MADRS score 11–30)
- ✓Adequate cognitive function (MMSE ≥25)
- ✕Current use of fatty acid or fish oil supplements
- ✕High fish consumption (>6 oz/week in prior month)
- ✕Severe depression
- ✕Suicidal ideation
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Fish Oil as an Adjunct Therapy for Depression in Multiple Sclerosis
In Brief
A Phase 2 clinical trial evaluating Fish oil concentrate and Placebo for Multiple Sclerosis and Depression. Completed, enrolled 39 participants across 1 site.
Detailed Summary
This study will determine whether fish oil can reduce depression in people with multiple sclerosis (MS) who are mild to moderately depressed and are currently taking antidepressant medication. Study hypothesis: Three months of fish oil supplementation will improve depression scores on the Montgomery-Asberg depression rating scale (MADRS) or Beck Depression Inventory (BDI) better than placebo.
Study Details
Timeline
Interventions
fish oil concentrate at a daily dose of 6 grams (2.1 gram EPA and 1.5 gram DHA).
soybean oil with 1% fish oil at a daily dose of 6 grams