At a glance
ClinicalIndex Comparison Record- ✓Admitted to trauma ICU (TICU) and intubated with mechanical ventilation within 24–48 hours of admission
- ✓Comatose and intubated patients included as they represent highest risk for respiratory infection
- ✕Witnessed aspiration or confirmed post-obstructive pneumonia (e.g., advanced lung cancer)
- ✕Known hypersensitivity to chlorhexidine
- ✕Thrombocytopenia (platelet count <40) or INR >2, or other coagulopathy
- ✕Do not intubate order in place
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Oral Health and Ventilator-associated Pneumonia
In Brief
A Phase 2 clinical trial evaluating chlorhexidine gluconate oral rinse (0.12%) and placebo for Pneumonia. Completed, enrolled 175 participants across 1 site.
Detailed Summary
Recent studies have found that poor oral hygiene may foster the colonization of the oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care unit (ICU) patients. Thus, improvements in oral hygiene in MV-ICU patients may prevent ventilator-associated pneumonia (VAP). The specific aims of this investigation are: 1) to organize the necessary infrastructure to develop and perform a pilot clinical trial to evaluate alternative oral hygiene procedures to prevent VAP; 2) to use this organization to perform a pilot clinical trial to determine if the use of oral topical chlorhexidine gluconate (CHX) will prevent dental plaque, oropharyngeal colonization by respiratory pathogens, and VAP in MV-ICU patients.
Study Details
Timeline
Interventions
chlorhexidine gluconate oral rinse