At a glance
ClinicalIndex Comparison Record- ✓History of myocardial infarction
- ✓Statin therapy indicated (either currently on statin or requires initiation)
- ✓No clear indication for folic acid supplementation
- ✕Plasma total cholesterol already <3.5 mmol/l in patients on statin therapy, or <4.5 mmol/l in statin-naive patients
- ✕Chronic liver disease
- ✕Severe renal disease or evidence of renal impairment
- ✕Inflammatory muscle disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
SEARCH: Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
In Brief
A Phase 3 clinical trial evaluating Simvastatin 20 mg daily, Folic acid 2 mg + vitamin B12 1 mg daily, and 2 other interventions for Cardiovascular Disease. Completed, enrolled 12,064 participants across 1 site.
Detailed Summary
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive cholesterol lowering regimen using 80 mg simvastatin daily produces a larger and worthwhile reduction in cardiovascular events compared with a standard 20 mg daily regimen and whether reducing blood homocysteine levels with a daily dose of folic acid 2 mg + vitamin B12 1 mg compared with matching placebo produces a worthwhile reduction in vascular disease.
Study Details
Timeline
Interventions
Simvastatin 20 mg tablet once daily
Folic acid 2 mg + vitamin B12 1 mg tablet once daily
Simvastatin 80 mg tablet once daily
Placebo vitamin B12/folic acid tablet once daily