CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 110 enrolled
Drug / intervention
Semantic Feature Analysis (SFA)Trainingbehavioral
Likely dose
Semantic Feature Analysis (SFA) training delivered by speech-language pathologistAI-extracted
Key inclusion· 5
  • Diagnosis of Wernicke's, Broca's, or Conduction aphasia with significant word-retrieval deficits
  • At least 6 months post-onset of single, left-hemisphere stroke
  • Minimum of high-school education
  • Visual and auditory acuity sufficient for experimental tasks
Key exclusion· 5
  • Diagnosed mental illness other than depression
  • Neurological condition other than that which resulted in aphasia
  • History of alcohol or substance abuse
  • Non-native English speaker

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00125242
NCT00125242N/ACompleted

Word-Retrieval for Aphasia: Facilitation of Generalization

US Department of Veterans Affairs·interventional·Posted Jul 29, 2005·Updated Dec 24, 2014

In Brief

A clinical study evaluating Semantic Feature Analysis (SFA)Training for Aphasia and 2 related conditions. Completed, enrolled 110 participants across 1 site.

Detailed Summary

The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categories of words (e.g., animals, tools, fruits). The treatment is also designed to be used as a search strategy in instances of word-finding difficulty. The study was devised to evaluate the extent to which treatment increases the ability to recall trained, as well as untrained, words.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 29, 2005
Enrollment StartJul 1, 2005
Primary CompletionFeb 1, 2009
Study CompletionApr 1, 2013
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 20.9 years ago

Interventions

Semantic Feature Analysis (SFA)Trainingbehavioral

SFA entails having the speech-language pathologist (SLP) guide the participant through generation of pertinent semantic features for pictured treatment items (e.g., category membership, physical description, location of item in context, personal associations, action associated with item). For some participants, treatment items were grouped according to typicality of category membership (e.g,, a robin-typical bird and penguin-atypical bird). Training of atypical items may stimulate a broader semantic activation of the category and thus, may promote greater generalization. Treatment was applied sequentially to sets of items in the context of single-subject, multiple baseline designs. In this way, replication of treatment effects could be evaluated within and across participants. Treatment was administered by certified SLPs three times per week until prescribed accuracy levels were met during nontreatment probes or a maximum number of treatment sessions was completed.