At a glance
ClinicalIndex Comparison Record- ✓History of low back pain for at least 6 months, with or without radiation to leg or buttocks
- ✓Age 18 years or older
- ✓Visual analogue scale pain score greater than 50 mm
- ✓Generally stable health
- ✕Low back pain associated with systemic signs or symptoms (fever, chills)
- ✕Evidence of rheumatoid arthritis, ankylosing spondylitis, acute vertebral fractures, fibromyalgia, history of back surgery or tumor
- ✕Active litigation, disability claim, or workers' compensation related to back pain
- ✕Neurologic disorder, including history of seizures
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
D-Cycloserine in the Management of Chronic Low Back Pain: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
In Brief
A Phase 2 clinical trial evaluating D-cycloserine and placebo for Low Back Pain and Pain. Completed, enrolled 41 participants across 1 site.
Detailed Summary
Pre-clinical studies in rats suggest that D-cycloserine (DCS) is effective in the management of chronic neuropathic pain. This pilot study will attempt to determine the effect of D-cycloserine in the treatment of chronic low back pain. Other aims of this study are to determine the safety of D-cycloserine in the treatment of chronic low back pain and to determine which pain measurement scales are best at measuring the efficacy of treatment.
Study Details
Timeline
Interventions
D-cycloserine 50 mg bid; D-cycloserine 100 mg bid; D-cycloserine 200 mg bid
placebo bid