CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 60 enrolled
Drug / intervention
Oxford street +1 moreother
Likely dose
Not stated in record
Key inclusion· 3
  • ✓Asthma severity classified as WHO GINA Steps 1–2 (mild) or Step 3 (moderate)
  • ✓Confirmed airway hyperresponsiveness (PC20 <8 mg/mL methacholine) or reversibility (≥12% FEV1 improvement after short-acting β-agonist)
  • ✓Baseline lung function assessment: methacholine challenge if FEV1 >80% predicted, airways reversibility testing if FEV1 <80% predicted
Key exclusion· 0

None specified.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00127062
NCT00127062N/ACompleted
CompareCT.gov

Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street

Imperial College London·interventional·Posted Aug 5, 2005·Updated Nov 5, 2019

In Brief

A clinical study evaluating Oxford street and Hyde park for Asthma. Completed, enrolled 60 participants.

Detailed Summary

Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma. The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAsthma
Countries--
CollaboratorsHealth Effects Institute

Timeline

N/ACompletedFinished
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 5, 2005
Enrollment StartMay 1, 2003
Primary CompletionAug 1, 2006
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 20.9 years ago

Interventions

Oxford streetother

2 h walk around Oxford street

Hyde parkother

2 h walk around Hyde park