At a glance
ClinicalIndex Comparison Record- ✓Diagnosed osteoarthritis of the hip or knee per American College of Rheumatology guidelines
- ✓Requires NSAIDs to control osteoarthritis pain
- ✕Prior surgery on the index joint
- ✕History of rheumatoid arthritis or fibromyalgia syndrome
- ✕Active gastrointestinal or cardiovascular disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Double-Blind Parallel-Group Randomized Study Of Efficacy And Safety Of "Continuous Use" Of Celecoxib Vs. The "Usual Use" Of Celecoxib In The Treatment Of Subjects With Chronic Osteoarthritis Of The Hip Or Knee Who Require an Anti-inflammatory Medication for Control Of Their Pain
In Brief
A Phase 4 clinical trial evaluating Celecoxib for Osteoarthritis, Knee and Osteoarthritis, Hip. Completed, enrolled 875 participants across 124 sites in 8 countries.
Detailed Summary
To determine whether "continuous use" of celecoxib over a 6-month period is more efficacious than "usual or intermittent use" in preventing spontaneous osteoarthritis flares of the knee and hip.
Study Details
Timeline
Interventions
24 weeks of study treatment: 2 weeks open-label celecoxib 200 mg daily followed by 22 weeks of randomized double blind celecoxib 200 mg daily. Placebo used as flare medication when directed.
24 weeks of study treatment: 2 weeks open-label celecoxib 200 mg daily followed by 22 weeks of randomized double blind placebo daily. Usual or intermittent use of celecoxib 200 mg daily as flare medication when directed.