At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of optic nerve hypoplasia (ONH), diagnosed at age ≤2 years
None specified.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
In Brief
A Phase 4 clinical trial evaluating Nutropin AQ for Growth Hormone Deficiency and 2 related conditions. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Hypotheses: 1. The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is commonly thought. 2. Early treatment of children with ONH and GH-deficiency can prevent adverse outcomes. Aims: 1. Determine the prevalence and types of endocrinopathies in children diagnosed with ONH. 2. Correlate endocrine outcome with radiographic, ocular, and developmental findings in children with ONH. 3. Examine the effect of GH treatment on growth and obesity in children with ONH, GH-deficiency, and either subnormal or normal growth compared to children with ONH that are not GH-deficient. 4. Compare growth outcomes between children with isolated GH-deficiency and those with multiple hormone deficiencies.
Study Details
Timeline
Interventions
Daily injection. Dosage dependent on weight.