CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 50 enrolled
Drug / intervention
Methadone +1 moredrug
Likely dose
Morphine 2 mg initial dose with 1 mg boluses every 10 minutes; methadone 1 mg combined with morphine 1 mg on second request in combination armAI-extracted
Key inclusion· 5
  • ✓Undergoing retroperitoneal lymph node dissection
  • ✓Planned post-operative analgesia with PCA at 1 mg continuous infusion and 1 mg bolus every 10 minutes
  • ✓Age 18 years or older
  • ✓English-speaking
Key exclusion· 7
  • ✕Known hypersensitivity to methadone or morphine
  • ✕History of substance abuse (past or present)
  • ✕Prior methadone treatment
  • ✕Chronic pain requiring daily analgesic use for more than 3 months

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00142519
NCT00142519Phase 2Completed
CompareCT.gov

Translational Studies in Analgesic Pharmacology: Analgesic Synergy in Clinical Pain. A Phase 2 Study Comparing a Single Dose of a 1:1 Combination of Methadone and Morphine With Morphine Alone in Patients With Post-operative Pain.

Memorial Sloan Kettering Cancer Center·interventional·Posted Sep 2, 2005·Updated Mar 15, 2019

In Brief

A Phase 2 clinical trial evaluating Methadone and methadone and morphine for Pain. Completed, enrolled 50 participants across 1 site.

Detailed Summary

This is a randomized Phase II study testing the effectiveness of the combination of morphine and methadone versus morphine alone in relieving pain. A second goal is to further evaluate any side effects of the combination of morphine and methadone.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 2, 2005
Enrollment StartMar 1, 2005
Primary CompletionJul 1, 2018
TodayJul 2, 2026
Enrollment to primary: 13.3 yearsPosted 20.8 years ago

Interventions

Methadonedrug

Upon the 1st request for analgesic medication morphine 2 mg, upon the 2nd request for analgesic medication morphine 2 mg

methadone and morphinedrug

Upon the 1st request for analgesic medication morphine 2 mg, upon the 2nd request for analgesic medication morphine 1 mg and methadone 1 mg