CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 336 enrolled
Drug / intervention
Nebivolol (NEB) +1 moredrug
Likely dose
Nebivolol 5 mg once daily or Metoprolol 100 mg once dailyAI-extracted
Key inclusion· 2
  • ✓Prior completion of nebivolol study
  • ✓Stage 1-2 Hypertension at baseline of initial study
Key exclusion· 2
  • ✕Recent myocardial infarction or stroke
  • ✕Contraindications to beta blocker therapy

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00142584
NCT00142584Phase 3Completed
CompareCT.gov

An Open-label, Randomized Study Evaluating the Long-term Effects of Metoprolol (MET) Versus Nebivolol (NEB) as Monotherapy or in Combination With Amlodipine or Hydrochlorothiazide for the Treatment of Patients With Hypertension

Mylan Bertek Pharmaceuticals·interventional·Posted Sep 2, 2005·Updated Mar 15, 2022

In Brief

A Phase 3 clinical trial evaluating Nebivolol (NEB) and Metoprolol (MET) for Hypertension. Completed, enrolled 336 participants across 1 site.

Detailed Summary

The purpose of this study is to evaluate long-term safety,tolerability and blood pressure effects of metoprolol versus nebivolol in patients with hypertension. These drugs may be given alone or in combination with other drugs that are commonly used in the treatment of hypertension

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension
CountriesUnited States
Collaborators--

Timeline

Phase 3CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 2, 2005
Enrollment StartAug 1, 2005
Primary CompletionMar 1, 2008
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 20.8 years ago

Interventions

Nebivolol (NEB)drug

Patients randomized to nebivolol will initiate therapy with nebivolol 5 mg once daily for 4 weeks.

Metoprolol (MET)drug

Patients randomized to metoprolol will initiate therapy with 100 mg once daily for 4 weeks.