At a glance
ClinicalIndex Comparison Record- ✓ICD indications (Class I-IIA) per guidelines for primary or secondary prevention in CAD or non-CAD patients
- ✓Already implanted with Medtronic Marquis family ICD capable of ATP for FVT via VF
- ✕Life expectancy <1 year from non-cardiac chronic disease
- ✕On heart transplant list with expected transplant <1 year
- ✕Age <18 years
- ✕ICD replacement or upgrade procedures (single chamber to dual chamber)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
ADVANCE-D: ATP Delivery for Painless ICD Therapy
In Brief
A Phase 4 clinical trial evaluating Implantable Cardiac Defibrillator for Tachycardia, Ventricular and Ventricular Fibrillation. Completed, enrolled 925 participants across 1 site.
Detailed Summary
The purpose of this study is to estimate and quantify the difference in efficacy of two sequences of ATP therapies (burst 15 pulses, 88% versus burst 8 pulses, 88%) during an episode of spontaneous rhythms classified as fast ventricular tachycardia (FVT) via ventricular fibrillation (VF) in patients who have a Class I or II A indication for ICD implantation, and thus to promote the "painless" therapy aspect of ICD treatment and improve quality of life outcomes for patients.
Study Details
Timeline
Interventions
Medtronic Marquis Family ICD, capable of Anti Tachy Pacing (ATP) for Fast Ventricular Tachycardia (FVT) via Ventricular Fibrillation (VF) zone