At a glance
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"The CHRONOS Study: Can the Sleep-deprivation Induced Antidepressive Effect in Patients With Major Depression be Sustained by Correction of Diurnal Rhythms, Long Term Light Treatment and Duloxetine Treatment?"
In Brief
A clinical study evaluating Sleep deprivation, Light therapy, and 3 other interventions for Major Depression. Completed, enrolled 75 participants across 1 site.
Detailed Summary
The primary objective of the present study is to examine whether the combination of the antidepressant duloxetine and chronotherapeutic methods (including sleep deprivation, light therapy, and maintaining a regular sleep-wake rhythm) in patient with major depression, will induce an immediate improvement from depression and whether this antidepressive effect will be maintained in the long term (29 weeks). Patient will be randomised to the above mentioned treatment or to an active group receiving exercise.
Study Details
Timeline
Interventions
3 days with a normal night between
Daily light therapy for 29 weeks
Keeping the day-night cycle constant by use of educational measures
Moderate intensity daily exercise for 30 minutes at least
60 mg daily
60 mg daily