CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 193 enrolled
Drug / intervention
Cognitive Behaviour Therapy (CBT) +1 morebehavioral
Likely dose
8 telephone CBT counselling sessions plus psycho-educational bookletAI-extracted
Key inclusion· 2
  • Patients with coronary heart disease receiving their first ICD implant for secondary prevention of SCD
  • Patients receiving first ICD implant for primary prevention of SCD with underlying hypertrophic cardiomyopathy
Key exclusion· 3
  • Unable to read or understand English
  • Evidence of psychosis, dementia, or cognitive impairment documented in hospital records
  • Receiving ICD for primary prevention (except HCM patients)

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00152763
NCT00152763Phase 3Completed

Psychological Support for Patients With an Implantable Cardioverter Defibrillator

University Health Network, Toronto·interventional·Posted Sep 9, 2005·Updated Jan 28, 2011

In Brief

A Phase 3 clinical trial evaluating Cognitive Behaviour Therapy (CBT) and Usual Cardiac Care (UCC) for Anxiety and Depression. Completed, enrolled 193 participants across 1 site.

Detailed Summary

About 30% of patients survive a cardiac arrest, and the majority of these receive an implantable cardioverter defibrillator (ICD) for prevention of sudden cardiac death (SCD). While ICD therapy offers survival benefit over drug therapy, there remain significant quality of life (QL) issues. About 50% of patients experience chronic anxiety about receiving an ICD shock. Anxiety and depression in turn appear to predispose to more arrhythmias necessitating ICD therapy. The aims of the current study are: 1. to evaluate a 8-session psychosocial intervention to help patients cope effectively with receiving an ICD for secondary prevention of SCD, 2. to determine if baseline measures of depression and anxiety predict ICD therapies (i.e., anti-tachycardia pace terminations and shocks); and 3. to explore if the psychosocial intervention results in less need for appropriate ICD therapies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnxiety, Depression
CountriesCanada
Collaborators--

Timeline

Phase 3CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 9, 2005
Enrollment StartOct 1, 2003
Primary CompletionSep 1, 2007
Study CompletionNov 1, 2007
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 20.8 years ago

Interventions

Cognitive Behaviour Therapy (CBT)behavioral

Cognitive behavior therapy tailored to psychological adaptation to an ICD, included 8 telephone counselling sessions, plus psycho-educational booklet and a therapist manual.

Usual Cardiac Care (UCC)other

Usual cardiac care (UCC) was defined as whatever the respective ICD treatment sites routinely offer their patients. All patients received standard educational materials explaining their heart disease and the ICD device. Follow-up appointments include device interrogation (i.e., to extract arrhythmia events and ICD therapies) and trouble-shooting at 6-months intervals, cardiac care as necessary, and nonsystematic supportive reassurance delivered informally in the clinic. Each centre also had access to a cardiac rehabilitation program and psychiatric consultation as needed.