At a glance
ClinicalIndex Comparison Record- ✓Prior myocardial infarction with CK elevation >3000
- ✓Status post revascularization therapy (PCI or CABG)
- ✓Clinically stable with regular outpatient follow-up
- ✓NYHA Class II-III heart failure
- ✕Sustained ventricular arrhythmia
- ✕Hypertrophic cardiomyopathy
- ✕Intolerance to exercise program
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
An Association Study Between Cardiac Rehabilitation and Stem Cell Mobilization in Patients With Myocardial Infarction
In Brief
A clinical study evaluating cardiac rehabilitation for Myocardial Infarction. Completed, enrolled 58 participants across 1 site.
Detailed Summary
One emerging concept is that some form of injury or inflammation is a prerequisite for the success of circulating-cell participation in differentiated tissue structure and function. Once reperfusion is achieved in acute myocardial infarction, an intense inflammatory cascade is unleashed. The architecture of the left ventricle rearranges, leading to ventricular remodeling. The "homing process"involves stem cell migration to the sites of injury or ischemia, which provides an environment that is favorable to growth and function. This microenvironment is a stimulus for homing and differentiation of stem cells of the appropriate lineage. It increases vascular permeability and expression of adhesion proteins like integrin, along with homing receptors that facilitate the attachment, which is mediated by cell-to-cell contact and chemoattractant release from local tissue injury.The migratory capacity of stem cells might be dependent on natural growth factors such as vascular endothelial growth factor (VEGF) , stromal cell-derived factor-1 (SDF-1)and stem cell factor (SCF).The expression of VEGF ,SDF-1 and SCF is highly up-regulated in hypoxic tissue, supporting the hypothesis that these factors may represent homing signals crucial to the recruitment of circulating progenitor cells to assist the endogenous repair mechanisms in the infarcted tissue. This study will examine whether cardiac rehabilitation increases the concentration of stem cell factors released into the bloodstream and if these factors are correlated with the improvement of heart function.
Study Details
Timeline
Interventions
Those in the training group participated in a 3-month rehabilitation training program at an exercise intensity of 55% to 70% of peak oxygen uptake (VO2); those in the nontraining group continued their usual lifestyle.