CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 38 enrolled
Drug / intervention
sertraline +1 moredrug
Likely dose
Flexible dose sertralineAI-extracted
Key inclusion· 5
  • ✓Video EEG confirmed diagnosis of NES
  • ✓At least one nonepileptic seizure per month
  • ✓Comorbid depression, anxiety, or PTSD
  • ✓Able to complete self-report symptom scales
Key exclusion· 6
  • ✕Equivocal EEG findings
  • ✕Current suicidality, litigation, or self-mutilation
  • ✕Using MAOIs, pimozide, or sumatriptan
  • ✕Allergy or sensitivity to sertraline

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00159965
NCT00159965Phase 4Completed
CompareCT.gov

Treatment for Psychogenic Nonepileptic Seizures: A Pilot, 12 Week, Prospective, Randomized, Placebo-controlled, Double-blind, Clinical Trial of Sertraline in the Treatment of Comorbid Psychiatric Disorders in NES

Rhode Island Hospital·interventional·Posted Sep 12, 2005·Updated Nov 20, 2014

In Brief

A Phase 4 clinical trial evaluating sertraline and placebo for Convulsion, Non-Epileptic and 3 related conditions. Completed, enrolled 38 participants across 1 site.

Detailed Summary

The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES. The purpose of this study is to provide pilot testing and data to inform the future randomized controlled trial based on the hypothesis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsConvulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
CountriesUnited States
CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS)

Timeline

Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 12, 2005
Enrollment StartDec 1, 2003
Primary CompletionJun 1, 2008
Study CompletionJun 1, 2009
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 20.8 years ago

Interventions

sertralinedrug

flexible dose sertraline

placebodrug

flexible dose placebo